WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cup s 2
Allergen source: Major taxonomic group: Plantae Pinopsida
Order: Cupressales
Species: Cupressus sempervirens (Common cypress)
NCBI Taxomony ID: 13469
Biochemical name:Polygalacturonase
Allergenicity:sera from 19 of 31 subjects with airway allergy in areas exposed to Common cypress (Curessus sempervirens) were positive to a 43 kDa protein based on immunoblots. The protein was characterized and demonstrated to be highly identical to Jun a 2 (~95% identity) and to Cha o 2 (80%).
Allergenicity reference:PubMed:28439939
Route of allergen exposure:Airway
Date Created:29-05-2017
Last Updated:2019-08-09 07:16:52
Submitter Info:
Name:Pascal Ponset
Institution:Institut Pasteur
City:Paris, France
Submission Date:2016-12-09


Posted: 30 Nov 2017

Ten reads of LC-MSMS produced 33 overlapping peptides with high identity match to a homologous protein from Cupressus arizonica and to Juniperus ashei, with >74% coverage. Edmand degradation was used to identify the N-terminus. That sequence was submitted to UniProt as C0HKB1, which is not yet posted. Note the IgE binding to this protein in Allergy 2017 72(11):1806 shows total inhibition with bromelain. In addition, the sequence entered here and UniProt indicates many gaps as this was LC/MSMS

Posted: 22 Dec 2017

Note that the Uniprot entry for the protein sequence shows a number of gaps between peptide segments, and BLAST to the nearest sequence suggests that there are many gaps. Thus the UniProt sequence C0HKB1 is likely to be wrong.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cup s 2.0101  C0HKB1