WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Fag e 4
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Caryophyllales
Species: Fagopyrum esculentum (Common buckwheat)
NCBI Taxomony ID: 3617
Obsolete name:Fa-AMP
Biochemical name:Hevein-like antimicrobial peptide
MW(SDS-PAGE):3.9 kDa
Allergenicity:Seven serum donors with convincing case histories of buckwheat allergy were tested. Food challenges were performed with positive outcome in 3/7 patients whereas not done in 4/7. SPTs were performed using total extract of the source as well as for oral food challenges. Serum derived IgE to native proteins from the extract was tested by western blot (6/7 positive). 5/7 samples were positive to purified Fag e 4 in ELISA. Natural exposure is by ingestion. Controls were performed with sera from 5 healthy donors, and 28 sera from atopic controls.
Allergenicity reference:PubMed:29171912
Route of allergen exposure:Food
Date Created:21-04-2017
Last Updated:2023-03-15 17:35:43
Submitter Info:
Name:Karin Hoffmann-Sommergruber
Institution:Medical University of Vienna
City:Vienna, Austria
Submission Date:2017-02-13


Posted: 21 Apr 2017

Fag e 4 used as parent number since other members of Caryophyllales have Oleosin-like protein as #1, and #2 and #3 are already used.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Fag e 4.0101  P0DKH7 
Fag e 4.0102  P0DKH8