WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Der f 23
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Sarcoptiformes
Species: Dermatophagoides farinae (American house dust mite)
NCBI Taxomony ID: 6954
Biochemical name:Peritrophin-A-like protein
MW(SDS-PAGE):19 kDa (Der f 23.01), 8 kDa (Der f 23.02)
Allergenicity:Subjects clinical history was recorded with symptoms of rhinitis or bronchial asthma. Serum IgE reactions to Der f 23.0101 were measured including western blots, dot blots and ELISA, with 72 positive reactors out of 129 patients, and 31 negative controls for IgE binding. SPT was positive for 3 subjects out of 10 patients and 10 controls. E. coli produced recombinant protein was used in IgE binding and SPT tests.
Allergenicity reference:PubMed:31173194
Route of allergen exposure:Airway
Date Created:04-05-2018
Last Updated:2023-11-09 14:37:53
Submitter Info:
Name:Kunmei Ji, Jiajie Chen
Institution:Shenzhen University Health Center
City:Shenzhen, China,
Submission Date:2018-04-19


Posted: 03 Nov 2022

Der f 23.01 (19 kDa) differs from Der f 23.02 (8 kDa) by two large insertions in the sequence, while the overlapping parts of the protein sequences are identical. The shorter isoallergen (i.e. Der f 23.02) corresponds in its length to Der p 23.01 with 76% amino acid sequence identity.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Der f 23.0101KU166910ALU66112A0A0U3JM875ZJL
Der f 23.0201KM009999AIO08855A0A088SAW7