WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Lat c 6
Allergen source: Major taxonomic group: Animalia Chordata
Order: Perciformes
Species: Lates calcarifer (Barramundi)
NCBI Taxomony ID: 8187
Biochemical name:Collagen alpha
MW(SDS-PAGE):130 kDa to 140 kDa
Allergenicity:Lat c 6 Allergenicity: Sera of 87 fish-allergic patients were tested for IgE binding to a pool of barramundi, Atlantic salmon and Yellowfin tuna collagens by ELISA. 19 patients were positive. Of those, 13 sera were tested in immunoblots to check IgE binding to collagen from specific fish species and to specific collagen alpha chains. Of 13 sera tested in immunoblot, IgE from all 13 bound to collagen alpha 1 chain from muscle tissue of barramundi. 11 of 13 bound to alpha 2 chain from muscle and to alpha 1 and alpha 2 chains from skin. Basophil activation test was performed with whole blood of one of the collagen-sensitized patients, using barramundi muscle collagen as stimulant of basophils. The result was positive.
Allergenicity reference:PubMed:32389794
Route of allergen exposure:Food
Date Created:18-04-2019
Last Updated:2021-01-02 21:29:42
Submitter Info:
Name:Tanja Kalic; Andreas L Lopata
Institution:Medical University of Vienna; James Cook University
City:Vienna, Austria; Townsville, Australia;
Submission Date:2019-03-23


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Lat c 6.0101XM_018666207.1XP_018521723.1  
Lat c 6.0201XM_018698476.1XP_018553992.1  
Lat c 6.0301XM_018666614.1XP_018522130.1