WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cor a 15
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Fagales
Species: Corylus avellana (Hazelnut)
NCBI Taxomony ID: 13451
Biochemical name:Oleosin
Allergenicity:Pediatric food allergic subjects, 17 tested positive for IgE binding out of 26 subjects to natural and recombinant protein. There were 5 negative controls. IgE binding was with 1D and 2D immunoblots from oilbody extracts. Also 2 ug of recombinant protein could inhibit IgE binding. Test subjects, 30 of 30 tested positive by SPT to hazelnut. 18 of 30 subjects were positive by in vivo challenge to whole seed.
Allergenicity reference:PubMed:34146442
Route of allergen exposure:Food
Date Created:07-07-2019
Last Updated:2023-07-17 18:17:06
Submitter Info:
Name:Maria Gabriella Giuffrida; Giovanna Monti
Institution:CNR, ISPA; Regina Margherita Children
City:Grugliasco, Italy; Turin, Italy;
Submission Date:2019-06-06


Posted: 07 Jul 2019

I first put this in Cor a 12.02. The submitter objected and in reviewing oleosins, I realized that it is the irregular Amino and Carboxy ends that are the unique sequences. The middle sequence is conserved as a trans-lipid section in oleosins. The IgE binding must be in the ends.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cor a 15.0101MK737923QEM21451C0HM28