ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Tyr p 1
Lineage: Source: Animalia Arthropoda
Order: Astigmata
Species: Tyrophagus putrescentiae (Storage mite)
Biochemical name:Cysteine protease
MW(SDS-PAGE):25 kDa
Allergenicity:298 subjects attending the Taichung Veterans General Hospital were recruited with at least asthma, rhinitis, atopic dermatitis or eczema. They were tested by SPT to recombinant protein. IgE binding tested by ELISA to recombinant protein, cloned by PCR. Indirect basophil activation was tested. 65 of 298 were positive by ELISA, 60 of 106 were positive by SPT and 35 of 30 positive by Basophil activation.
Allergenicity reference:32887361
Route of allergen exposure:Airway
Date Created:2020/9/8
Last Updated:2020-09-08 18:05:04
Submitter Info:
Name:En-Chih Liao
Institution:Mackay Medical College
City:Taipei City, Taiwan
Email:enchih@mmc.edu.tw
Submission Date:2020-08-26

Comments

Posted: 08 Sep 2020

Sequenced originally by FT Chew in ~ 2008.
Then the work by Liao. It is not clear whether this is a prepro sequence that will be reduced in processing, and then be at 25 kDa. Based on the seqeunce, it should be >31 kDa. The authors did not show the sequence in their MDPI 8 Sept 2020 publication. THey do not claim having tested the AA sequence.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Tyr p 1.0101DQ983317ABM53753DQ983317