Allergen Details:
| Allergen name: | Can s 7 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Rosales Species: Cannabis sativa (Indian hemp) NCBI Taxomony ID: 3483 |
| Biochemical name: | Thaumatin-like protein |
| Allergenicity: | Three groups of Cannabis-exposed subjects were tested: 1. 60 Cannabis-allergic patients as confirmed by SPT and specific IgE to Cannabis. 2. 10 pollen-allergic patients without Cannabis allergy, 3. 5 healthy controls. In an ELISA with rCan s 7.0101 (fusion protein of maltose-biding protein with the preprotein of Can s 7.0101), 16/60 (27%) cannabis-allergic patients, 2/10 atopic controls and none of the healthy controls had IgE to rCan s 7. In a passive mast cell activation test with rCan s 7, cells sensitized with 4/5 sera from Can s 7-sensitized cannabis-allergic patients, none of 5 atopic control subjects' sera and 1 of 3 healthy control subjects' sera were activated. |
| Allergenicity reference: | PubMed:37984436 |
| Route of allergen exposure: | Airway |
| Date Created: | 2023-11-08 |
| Last Updated: | 2024-03-08 15:35:57 |
| Submitter Info: | |
| Name: | Hans-Peter Rihs, Didier G Ebo |
| Institution: | Ruhr University Bochum, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA); Antwerp University Hospital (UZA), Dept. of Immunology, Allergology and Rheumatology |
| City: | Bochum, Germany; Edegem, Belgium |
| Email: | hans-peter.rihs@dguv.de; didier.ebo@uantwerpen.be |
| Submission Date: | 2023-08-22 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Can s 7.0101 | XM_030646437 | XP_030502297 |