Allergen Details:
| Allergen name: | Bet v 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fagales Species: Betula verrucosa (Betula pendula) (European white birch) NCBI Taxomony ID: 3505 |
| Biochemical name: | Pathogenesis-related protein, PR-10, Bet v 1 family member |
| MW(SDS-PAGE): | 17 kDa |
| Allergenicity: | Bet v 1 is responsible for IgE binding in more than 95% of birch pollen allergic patients |
| Allergenicity reference: | PubMed:6886253 |
| Route of allergen exposure: | Airway |
| Date Created: | 13-03-2003 |
| Last Updated: | 2019-07-16 00:30:20 |
| Submitter Info: | |
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Comments
See PLOS One Spiric et al., 2015, open access journal. Series of 9 Bet v 1 sequences added at request of Andreas Reuter, PEI, 27 Aug 2015, from 2D Gel and LC-MSMS proteomics of pollen extract. the 9 sequences listed here, match previous cDNA clones by others.
Bet v 1.0115
Bet v 1.0116
Bet v 1.0117
Bet v 1.0118
Bet v 1.0119
Bet v 1.0205
Bet v 1.0206
Bet v 1.0207
Bet v 1.0301
Proof of expression in pollen and high sequence identity to other Bet v 1 isoforms (1 at 75%, the remainder at 85-99% identity).
At its meeting in February 2013, the IUIS Allergen Nomenclature Sub-Committee decided to update the nomenclature of Bet v 1 isoallergens based on the following principles:
1. The database should contain only Bet v 1 sequences whose expression in pollen has been proved at least on the mRNA level.
2. Similar sequences are grouped as variants of an isoallergen if they show >90% sequence identity.
3. Different variant numbers are assigned only to variants with different protein sequences. Nucleotide sequences differing only be silent mutations are not distinguished by the allergen nomenclature.
As a consequence, the following entries were deleted:
Bet v 1.11-Bet v 1.13 and Bet v 1.15-Bet v 1.23.
The following variants were merged into a single entry:
Bet v 1.0101/0102/0103
Bet v 1.0401/0402 (now Bet v 1.0102)
Bet v 1.0601/0602 (now Bet v 1.0104)
Bet v 1.1401/1402 (now Bet v 1.0204)
The following entries were classified as variants of Bet v 1.01:
Bet v 1.01, Bet v 1.04-Bet v 1.08, Bet v 1.10 and Bet v 1.24-Bet v 1.30.
The following entries were classified as variants of Bet v 1.02:
Bet v 1.02, Bet v 1.03, Bet v 1.09 and Bet v 1.14.