ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cand a 1
Lineage: Source: Fungi Ascomycota
Order: Saccharomycetales
Species: Candida albicans (Common yeast)
Biochemical name:Alcohol dehydrogenase
MW(SDS-PAGE):40
Allergenicity:- Of 30 asthmatic patients with a positive skin test and RAST to C.albicans, 23 (77%) showed serum IgE binding to a 40 kD component on an immunoblot of C.albicans extract. - This 40 kD protein was cloned and identified as Cand a 1. IgE binding to both natural and rCand a 1 was demonstrated on immunoblot and in ELISA (medline 92136159).
Allergenicity reference:2665907
Route of allergen exposure:Unknown
Date Created:01-09-2003
Last Updated:2010-04-29 23:57:55
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Comments

Posted: 29 Oct 2014

Note the allegenicity in Shen et al., 1989, Clin Exp Allergy used immunoblots of extracts to with 30 allergic sera to identify 77% + IgE binding to a 40 kDa protein (Fig 2). The sequencing paper (Shen et al., 1991, Clin Exp Allergy) shows partial cloned sequence of Cand a 1 that matches a portion of their 350 aa sequence in locus CAA57342.1. So evidence is not against purified protein. REG

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cand a 1.0101X81694CAA57342P43067