ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contribution from IUIS, EAACI, and AAAAI organizations

Member Login

Allergen Details:

Allergen name: Pla a 3
Lineage: Source: Plantae Magnoliopsida
Order: Proteales
Species: Platanus acerifolia (London plane tree)
Biochemical name:Non-specific lipid transfer protein 1
MW(SDS-PAGE):10
Allergenicity:Of 58 plane pollen allergic patients, 45% showed IgE binding to purified nPla a 3 in immunoblot. The rates of sensitization to Pla a 3 in plane allergic patients with and without peach allergy were 61% and 18%, respectively.
Allergenicity reference:17250699
Route of allergen exposure:Unknown
Date Created:Nov 5 2006 2:40PM
Last Updated:2014-12-16 15:15:38
Submitter Info:
Name:Iris Lauer
Institution:Department of Allergology, Paul-Ehrlich-Institut
City:Langen, Germany
Email:lauir@pei.de
Submission Date:

Comments

Posted: 06 May 2015

on 5/6/2015 Andrea Wangorsch. of PEI sent a note and a submission to GenBank for a mature full length sequence of Pla a 3.0101, but there is a one-aa difference (last aa of 25) from the N-term sequencing in the I. Lauer paper for 3.0101, compared to the cDNA.In addition, Thermo Fisher has performed LC-MSMS on pollen sample and confirmed that the mature 3.0101 protein should NOT have the second V (position 25). Therefore we are replacing the N-terminal peptide sequence with the full-mature sequence determined by cDNA sequencing.
The original entry was ~ 2010, but the date of 6 May, 2015 is used for the updated cDNA sequence.

Sequence and data for Pla a 3.0201 was submitted 2015-05-06 REG

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Pla a 3.0101    
Pla a 3.0201