Allergen Details:
| Allergen name: | Cha o 3 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Pinopsida Order: Cupressales Species: Chamaecyparis obtusa (Japanese cypress) NCBI Taxomony ID: 13415 |
| Biochemical name: | Cellulase (glycosyl hydrolase) |
| MW(SDS-PAGE): | 63kDa |
| Allergenicity: | Fourteen of 16 Japanese pollen allergic subjects showed IgE binding to the pure protein in ELISA. Three of four had basophil activation (CD203c) positivity. All of these subjects were RAST class >2 positive. The 2016 publication in JACI demonstrates T cell reactivity as well as basophil activation. |
| Allergenicity reference: | PubMed:27237746 |
| Route of allergen exposure: | Airway |
| Date Created: | 25-08-2015 |
| Last Updated: | 2019-07-31 00:15:30 |
| Submitter Info: | |
| Name: | Toshihiro Osada |
| Institution: | Taiho Pharmaceutical Co. Ltd |
| City: | Ibaraki, Japan |
| Email: | toshi-osada@taiho.co.jp |
| Submission Date: | 2015-07-29 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cha o 3.0101 | HV942721 | GH5FP_CHAOB | C0HLA0 |
Note the nucleotide sequence was patented under the Genbank accession HV942721, so BLAST does not find the sequence. The sequence is published here with permission of the submitter.