Allergen Details:
| Allergen name: | Pan h 4 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Chordata Order: Siluriformes Species: Pangasianodon hypophthalmus (Striped catfish) NCBI Taxomony ID: 310915 |
| Biochemical name: | Tropomyosin alpha |
| MW(SDS-PAGE): | 35 kDa |
| Allergenicity: | Clinical data: A total of 80 fish-allergic patients were included in this study. All had a convincing history of IgE-mediated fish allergy and a sensitization to at least one fish species confirmed by skin prick test with commercial and in-house fish preparations. Eight patients reported typical IgE-mediated allergic reactions after ingestion of Pangasianodon hypophthalmus. As negative controls, 2 non-atopic individuals without history of type I allergy and 8 individuals with allergy to shellfish were used. Among those 10 individuals, only three individuals with shellfish allergy demonstrated IgE reactivity to this tropomyosin. IgE binding was positive in 27 of 80 subjects, and SPT in 61 of 80. |
| Allergenicity reference: | PubMed:32860256 |
| Route of allergen exposure: | Food |
| Date Created: | 21/9/2019 |
| Last Updated: | 2021-01-11 16:52:17 |
| Submitter Info: | |
| Name: | Thimo Ruethers; Andreas Lopata |
| Institution: | James Cook University |
| City: | Townsville, Australia |
| Email: | thimo.ruethers@my.jcu.edu.au; andreas.lopata@jcu.edu.au |
| Submission Date: | 2019-07-23 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pan h 4.0101 | XM_026925681.1 | XP_026781482 | ||
| Pan h 4.0201 | XM_026919627.1 | XP_026775428.1 |