ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Hev b 1
Lineage: Source: Plantae Magnoliopsida
Order: Malpighiales
Species: Hevea brasiliensis (Para rubber tree (latex))
Biochemical name:Rubber elongation factor
MW(SDS-PAGE):14 kDa
Allergenicity:PubMed:9389300: Of 140 patients with spina bifida (SB), 81% had IgE against nHev b 1, as measured by EAST. Of 105 health care workers (HCWs) allergic to latex, 52% had nHev b 1 specific IgE. In skin-prick test with nHev b 1, 10 of 14 patients with SB and 16 of 18 HCWs reacted to the allergen. - PubMed:8828541: None of 20 tested sera of latex-allergic adult patients tested showed IgE binding to nHev b 1 or rHev b 1 on immunoblot. However, both allergens were recognized by 2 serum pools (53 and 101 sera) of patients with SB. - PubMed:10691894: Hev b 1 was recognized in an IgE-ELISA by 10 of 31 (32%) sera from latex allergic HCWs and from 13 of 13 sera from latex allergic patients with SB.
Allergenicity reference:9389300882854110691894
Route of allergen exposure:Unknown
Date Created:03-07-2003
Last Updated:2018-05-22 18:36:04
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Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Hev b 1.0101X56535CAA39880P15252